Primary Hematopoietic and Lymphoid Tissue ›› Bone Marrow ›› Abnormal

Dysplastic Eosinophil*


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› Microscopic Features:

• 2-3x larger than a mature RBC
• Low nuclear to cytoplasmic (N/C) ratio (more cytoplasm than nucleus)
• Nucleus is mature and usually with 2 lobes connected by thin chromatin filament (some have 1 lobe or more than 2 lobes)
• Nucleoli are usually absent
• More cytoplasm with Abnormal secondary granules (usually darker in color resembling basophilic granules). The granules are usually heterogenous and sometimes vacuoles may also be noted.

› Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

• PB: None
• BM: None
• LN: None

› May Resemble:

• Eosinophil [Compare]
• Basophil [Compare]
• Neutrophil (mature) [Compare]
• Pseudo-Pelger Huet Neutrophil [Compare]
• Band Neutrophil [Compare]
• Neutrophil with toxic granules [Compare]

› Differential Diagnoses:

Associated with: Certain AMLs such as AML with Inv 16 or t(16;16) Certain Myeloid disorders/neoplasms Artifact of staining must be ruled out

› Classic Immunophenotype:

• N/A

› Cartoon Image:


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› Misc:

• May be associated with certain myeloid neoplasms such as AML with invresion 16 or t(16;16)